Almost a year has passed since I started my Ph.D. journey in the land of snow and maize. After four long lab rotations across three departments and hopping from one project to another, it is time to pick a permanent lab and a research direction.
I am happy to announce that I have officially joined the distinguished Department of Chemistry at my university and have begun my research at the Institute for Drug Discovery where I will work for the remaining period of my doctoral degree. I couldn’t be happier with my decision which was mainly determined by three aspects – my advisor/mentor, the research area and the lab (environment and members). It feels good to finally know where I am headed towards and not feel lost or uncertain. Every one of my rotations was unique and helped me learn the nitty-gritty of grad school. Moving forward, I will focus on brain-related disorders like Alzheimer’s Disease and work towards understanding a tiny piece of a large puzzle which may aid in finding a cure/prevention/slow down the progression of the disease. Specifically, the overarching theme of my work will be to identify and test compounds predicted for the disease by taking into account all the possible interactions between biomolecules in the protein universe (aka the proteome). Traditional drug discovery methods involve targeting a specific protein or a specific pathway and thereby limiting the possibility of finding successful leads. In reality, we know that one biomolecule interacts with several other biomolecules in several different pathways. Interactome-based drug discovery is promising because of its broader and quicker approach compared to the other mainstream pipelines that exist today.
One other major factor that helped me decide my major lab was the computation aspect involved in drug discovery research. Taking the challenging Computational Chemistry course this semester helped me take the first step towards learning about some of the components of computer-aided drug discovery. It is amazing how the two channels of research (wet lab and dry lab) finally come together in solving some of the major challenges in health and medicine. Anyway, I will continue to update here more on my day-to-day lab rat adventures. I am excited to start this new chapter of my life and see where it takes me! :)